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Mewtwo was created by humans 20 years before, but he managed to escape. Months before the events of the film, Harry Goodman was recruited by Howard Clifford to track down Mewtwo, which eventually led to his capture. Trapped in a spherical chamber, Mewtwo was used by Dr. However, Mewtwo was freed by Harry and his partner Pikachu, making Mewtwo realize that not all humans are evil. When Harry's car crashed in an ambush , Mewtwo came to his rescue and combined a dying Harry into Pikachu's body but also erased his memory, creating Detective Pikachu as a result.
Mewtwo has also appeared in various animated adaptations of the franchise. Kubo Masakazu, executive producer of Mewtwo Strikes Back , explained that they "intentionally avoid using the term 'kuron' [clone]… because the word has a frightening feel". Despite having a genome that is almost identical to Mew, Mewtwo's appearance is very different in comparison. Its appearance has been likened to "an over sized cross of cat, squirrel and kangaroo". As such, it can use telekinesis for flight ,  to shield itself, or to powerfully throw opponents aside.